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Research Group

Research

Publications

Chenming (Mike) Zhang

Associate Professor
210 Seitz Hall
540/231-7601
chzhang2@vt.edu
http://www.bse.vt.edu/Mike

Mike Zhang

Areas of Interest

Protein engineering, protein recovery, protein purification, drug delivery and vaccine development.

Education

Ph.D. Chemical Engineering, Iowa State University, Ames, IA, 1999

M.S. Physical & Analytical Chemistry, Iowa State University, Ames, IA, 1996

M.S. Metallurgical Physical Chemistry, University of Science and Technology Beijing, China, 1991

B.S. Metallurgical Physical Chemistry, University of Science and Technology Beijing, China, 1986

Professional Experience

2007 - present: Associate Professor, Biological Systems Engineering Department, Virginia Polytechnic Institute and State University, Blacksburg, VA

2001 - 2007: Assistant Professor, Biological Systems Engineering Department, Virginia Polytechnic Institute and State University, Blacksburg, VA

1999 - 2001: Scientist, Covance Biotechnology Services, Research Triangle Park, NC

1996 - 1999: Research Associate, Department of Chemical Engineering, Iowa State University, Ames, IA

1993 - 1997: Research Associate, Department of Chemistry, Iowa State University, Ames, IA

1991 - 1993: Product Manager and Engineer, Yitai New Technology Institute, Beijing, China

Teaching and Workshops

BSE 3524 Unit Operations in Bioprocess Engineering

BSE 4544 Protein Separation Engineering

BSE 5614 Advances in Recombinant Protein Production

Awards and Recognitions

Outstanding New Assistant Professor Award College of Engineering, Virginia Tech, 2004

NAE/IOM Young Investigator Travel Award (Vaccine-2006), 2006

National Academy of Engineering, Young Investigator Award/Vaccine, Production Starter Grant, 2006

Selected Publications

Lakshmi P., D. Bevan, C. Zhang. 2008. Quantifying protein microstructure and electrostatic effects on the change in Gibbs free energy of binding in immobilized metal affinity chromatography. Analytical Chemistry, 80(5): 1628-1640.

Matanin B., Y. Huang, X. Meng, C. Zhang. 2008. Purification of the major envelop protein GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) from native virions. , Journal of Virological Methods, 147:127-135.

Holler C., C. Zhang. 2008. Purification of an acidic recombinant protein from transgenic tobacco., Biotechnology & Bioengineering, 99(4):902-909.

Holler, C., Vaughan, D., and Zhang, C. 2007. Polyethyleneimine precipitation vs. anion exchange chromatography in fractionating recombinant beta-glucuronidase from transgenic tobacco extract. Journal of Chromatography A. 1142 98-105.

Pathange, L.P., Bevan, D.R., Larson, T.J., and Zhang, C. 2006. Correlation Between Protein Binding Strength on Immobilized Metal Affinity Chromatography and the Histidine-Related Protein Surface Structure. Analytical Chemistry. 78(13) 4443-4449.

Zhang, C. 2006. Protein recovery from tobacco extract by non-chromatographic methods. BioProcessing Journal 5(1):19-23.

Zhang, C., Medina-Bolivar, F., Buswell, S., and Cramer, C.L. 2005. Purification and stabilization of ricin B from tobacco hairy root culture medium by aqueous two phase extraction. Journal of Biotechnology. 117(1) 39-48.

Zhang, C. and Glatz, C.E. 2005. Applicability of the stoichiometric displacement model to description of the retention behavior of charged-fusion proteins during fast protein liquid chromatography. Journal of Chromatography A. 1069(1) 113-118.

Zhang, C., Lillie, R., Cotter, J., and Vaughan, D. 2005. Lysozyme purification from tobacco extract by polyelectrolyte precipitation. Journal of Chromatography A. 1069 (1) 107- 112.

Buswell, S., Medina-Bolivar, F., Chen, Q., Van Cott, K., and Zhang, C. 2005. Expression of porcine prorelaxin in transgenic tobacco. Annals of the New York Academy of Sciences 1041:77-81.

Patents

U.S. Patent 6,841,658 (2007). Purification of human Troponin I. The patent is being used by Diosynth Biotechnology to produce clinical trial materials.


Chenming (Mike) Zhang, Biological Systems Engineering, Virginia Tech.
Tel: 540-231-7601    Email: cmzhang @ vt.edu